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1994-10-25
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Document 2956
DOCN M94A2956
TI Impaired gastric empyting in patients with HIV infection.
DT 9412
AU Piot D; Gathe J Jr; Bernal A; Stool E; Clemmons J; Stenoien R; Goldstein
J; Park Plaza Hospital, Special Diseases Unit, Houston, Texas.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):186 (abstract no. PB0172). Unique
Identifier : AIDSLINE ICA10/94369619
AB OBJECTIVE: To detail characteristics of HIV infected patients with
gastric emptying disturbances (GED). METHODS: Retrospective chart review
of 18 patients followed prospectively by the authors. GED was documented
by nuclear medicine gastric emptying study. RESULTS: Patient
characteristics include: Age range 23-63; 16 males, 2 females; T-cell
profile range 16-466. All patients had one or more documented
infections: 14 CMV, 1 cryptosporidiosis, 5 mycobacteriosis, 1
cryptococcus. Symptoms included: nausea (17/18), vomiting (15/18),
abdominal pain (10/18), diarrhea (8/18), weight loss (8/18), abdominal
distention (4/18), aspiration pneumonia (1/18). Endoscopy findings
revealed retained food from meals > 12 hours after ingestion, gastric
bezoar, and undigested medicines. No specific histopathology was seen.
Calculated gastric T 1/2 emptying times were abnormal (> 85 minutes) in
17/20 studies, with a range of 20-300 minutes and a mean of 220 minutes.
Of the 18 patients, 5 improved, 6 stabilized, 7 died. CONCLUSIONS: 1.
GED can occur at any time during HIV infection once CD4 counts fall
below 500. 2. Symptomatic GED was usually discovered with a simultaneous
systemic infection. 3. Direct complications of GED include: a.
Aspiration pneumonia, b. Malnutrition, c. Malabsorption of oral
medications. 4. When GED is documented, important oral medications may
need to be given parenterally until GED is corrected. 5. Adjuvant
propulsion agents have been helpful, but the reversibility of GED
appears to be a reflection of time and the control of infections.
DE Adult Endoscopy, Gastrointestinal Female Gastric Emptying/*PHYSIOLOGY
Human HIV Infections/*PHYSIOPATHOLOGY Male Middle Age Retrospective
Studies Stomach/PHYSIOPATHOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).